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Contribuyen al peso de la evidencia las observaciones de mutagenia en bacterias en condiciones que favorecen la ruta del GSH/mercapturato/beta-liasa, la genotoxicidad en células de mamífero y la unión al ADN in vivo en ratas y ratones.
Contributing to the weight of evidence are observations of mutagenicity in bacteria under conditions that favor the GSH/mercapturate/-lyase pathway, genotoxicity in mammalian cells, and in vivo DNA binding in rats and mice.
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