Translation examples
5α-reduktaasit katalysoivat tiettävästi ainakin seuraavia reaktioita: Kolestenoni → 5α-Kolestanoni Progesteroni → 5α-Dihydroprogesteroni 3α-Dihydroprogesteroni → Allopregnanoloni 3β-Dihydroprogesteroni → Isopregnanoloni Deoksikortikosteroni → 5α-Dihydrodeoksikortikosteroni Kortikosteroni → 5α-Dihydrokortikosteroni Kortisoli → 5α-Dihydrokortisoli Aldosteroni → 5α-Dihydroaldosteroni Androsteenidioni → 5α-Androsteenidioni Testosteroni → 5α-Dihydrotestosteroni 5α-reduktaasin salpaajia kuten finasteridiä ja dutasteridiä käytetään lääkkeinä miestyypin kaljuuntumiseen.
The following reactions are known to be catalyzed by 5α-reductase: Cholestenone → 5α-Cholestanone Progesterone → 5α-Dihydroprogesterone 3α-Dihydroprogesterone → Allopregnanolone 3β-Dihydroprogesterone → Isopregnanolone Deoxycorticosterone → 5α-Dihydrodeoxycorticosterone Corticosterone → 5α-Dihydrocorticosterone Cortisol → 5α-Dihydrocortisol Aldosterone → 5α-Dihydroaldosterone Androstenedione → 5α-Androstanedione Testosterone → 5α-Dihydrotestosterone The mechanism of 5α reductase inhibition is complex, but involves the binding of NADPH to the enzyme followed by the substrate.
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