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The zebra fish is suitable for modelling the disease because the immune defence of the fish is very similar to that of people. The same applies to both the innate and acquired immunity,” Tiihonen says.
Seeprakala soveltuu mallintamaan tautia siksi, että sillä on hyvin samankaltainen immuunipuolustus kuin ihmisellä, sekä synnynnäinen että hankittu immuniteetti, Tiihonen kertoo.
Shortly thereafter, his team developed a line of red fluorescent zebra fish by adding a gene from a sea coral, and orange-yellow fluorescent zebra fish, by adding a variant of the jellyfish gene.
Onnistuneen geeniteknisen muokkauksen jälkeen kehitettiin punainen fluoresoiva seeprakala korallilajilta saadulla geenillä sekä keltainen seeprakala meduusalajin toisen geenin avulla.
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